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Figure 2.

Longitudinal series of isolates. Each series (collected from patients P01 to P16) is depicted as a row of dots to represent sampling time points. Colors indicate different RAPD genotypes, and relative dot size indicates patient lung function (%FEV) at that time point. Gray circles indicate no associated %FEV (percentage of predicted forced expiratory volume in 1 sec) measurement (also see For Sale Online Cheap Hot Sale Mens 05276 Loafers Crema Extra Weit 75 UK Rieker Discount Best Discount Finishline ucp6YjcwXr
).

View this table:
Table 1.

Summary of 16 longitudinal series

The majority of patients were colonized by subgroup A isolates (202 of 215 isolates) primarily from one of the major B. cenocepacia epidemic lineages. Except for the single patient P09 infected with subgroup B, all isolates from the same patient belonged to the same RAPD type. By using these 215 isolates, we conducted a comprehensive survey of clinically relevant phenotypes and carried out whole-genome sequence analysis of all isolates.

To understand how bacterial phenotypes change over time during chronic infections, we systematically cataloged phenotypic variation for all isolates. Specifically, we measured: growth in two liquid media types (lysogeny broth [LB]; and synthetic cystic fibrosis medium [SCFM]), swimming motility, biofilm formation, acute virulence in an insect model, and mucoidy morphotype ( Palmer et al. 2007 ). The results reveal extensive phenotypic variation among B. cenocepacia isolates both within and among RAPD types and within patient series. Detailed descriptions and results for each phenotype are in Womens Straightset Lace 317 3 Bass Trainers Lacoste Official Site xzPai
, Supplemental Table S1 , and Metcon Free Trainers In White Camo AH8141103 White Nike Outlet Shop For fIP9Wfvwf2
.

By considering these phenotypes on a global level, we found that RAPD genotype was a significant predictor of phenotypic variation, explaining between ∼20% and 50% of the variation ( Table 2 ; Supplemental Fig. S4 ). However, considerable variation was also seen within patient series and within RAPD type. We also identified progressive phenotypic changes in many longitudinal series ( Womens Simona Bootie HiTop Sneakers Esprit Fast Express Outlet Locations For Sale Outlet Largest Supplier 3jMdGF9Nmn
). Six of the 16 series showed progressive decreases in motility, five showed temporal changes in biofilm formation (two increasing and three decreasing), two showed decreases in acute virulence as measured in an insect model, none showed changes in mucoidy, and, finally, seven showed changes in one or more growth parameters.

View this table:
Table 2.

Correlation between RAPD type and clinically relevant phenotypes

View this table:
Table 3.

Percentage change per year in clinically relevant phenotypes across longitudinal series

Given that each individual phenotype could have a complex genetic basis, we examined pairwise phenotypic correlations across all isolates and for each RAPD type individually ( Latest Discount Sale Cupro Skirt YELLOW AUDREY I POP ART by VIDA VIDA Cheap 2018 Sale Excellent HygeXwWg
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A). This is not surprising; biofilm has been associated with persistent infection and not with acute virulence ( FOOTWEAR Boots Via Roma 15 Clearance Wholesale Price Discount Shop ChoAnTjRE
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). Overall, motility was positively correlated with biofilm formation and mucoidy (Spearman correlation, ρ = 0.48 and 0.40, respectively, adjusted P -value <0.0001) ( Fig. 3 A). A strong positive correlation was found between motility and biofilm formation for most RAPD genotypes, except for a negative correlation was seen for subgroup B RAPD44 isolates (ρ = −0.85, adjusted P -value = 0.001) ( Fig. 3 B–G).

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Where a local authority feels that an applicant is refusing to cooperate and that the refusal is 'deliberate and unreasonable', it can follow a specific procedure for notifying the applicant.

The information on this page applies only to homelessness applications made on or after 3 April 2018 .

on or after 3 April 2018

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An applicant refuses to cooperate when s/he does not take a step (or steps) in her/his 5495230 Womens Flatform Pumps North Star Free Shipping Low Price Fee Shipping Outlet Low Price Fee Shipping Comfortable Cheap Price 88rHBPSxb
. [1] This might be a step which:

In order for the applicant to be penalised, the refusal must have been deliberate and unreasonable.

An applicant cannot be found not to have cooperated with a step which was identified as a 'good idea' in her/his plan, but which s/he was not was required to take. TIA Casual Platform Sandals Black patent Asos Sneakernews Cheap Price Great Deals For Sale Genuine Sale Online Best Place Cheap Price 100% Guaranteed Cheap Price lmp77la7dn

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Neither 'deliberate' nor 'unreasonable' is defined in the Act or in the Romy 60 dusty glitter pump Jimmy Choo London Free Shipping Ebay IdlYUJXEtI
The Code suggests that a local authority follows a four stage determination to decide whether a failure to take a step was deliberate and unreasonable: [3]

The Code suggests that where an applicant appears not to be cooperating, the local authority should review its assessment of her/his needs and the appropriateness of the steps in the personalised housing plan. [4] It may be found that certain steps in the PHP are not reasonable, or have become unreasonable. For example, even if requiring an applicant to search for accommodation in a particular area at first seemed reasonable, it may be s/he has tried all of the private landlords in an area and none of them are willing to offer accommodation. In these circumstances, it is unlikely to be reasonable to require her/him to keep looking. If steps are not reasonable, or are no longer reasonable, then the applicant should be notified and should not face consequences for failing to take them. [5]

It may emerge during the authority's investigations (see below) that the applicant did not understand one of the steps in the plan (perhaps because of a language difficulty) and if so, s/he should not be found to have deliberately and unreasonably refused to cooperate. [6]

The Code requires that local authorities take into account any particular difficulties the applicant has in managing communication. It suggests, for example, that cooperation may be particularly difficult where an applicant is street homeless or moving between temporary places to stay. FOOTWEAR Espadrilles Marc Jacobs Outlet High Quality Authentic Sale Online Cheap Price From China Sale Visit New VGdoCtMX
The problems may be around, for example, an applicant having a learning disability or more practical issues such as being required to contact landlords and not having telephone access. In circumstances such as these, it is less likely that failing to cooperate would be counted as deliberate or unreasonable.

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- NewStem Formed with Support of The Hebrew University of Jerusalem -

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